[P4–240]: RELATIONSHIP BETWEEN STRUCTURAL CHANGES OF BRAIN AND COGNITIVE FUNCTION AND SURVIVAL RATE IN ALZHEIMER'S DISEASE PATIENTS

relationship of global and voxel-wise FDG SUVR, using both RStudio (global FDG SUVR) and VoxelStats (FDG SUVR in each image voxel), and decline in memory using the ADNImemory composite score (ADNI-MEM) measured yearly over 4 years time, adjusting for age, gender, education, and APOE ε4 carrier status. Results:The voxel-wise analyses showed that ADNI-MEM decline was predicted by decreased FDG SUVR in the left temporal lobe and precuneus in A+/T+MCI subjects (Fig 1) and in the inferior parietal lobe in A+/TMCI subjects (Fig 2). In addition, ADNI-MEM decline was predicted by globally decreased FDG SUVR in A+ MCI subjects. However, as the change in ADNI-MEM in the A+/ T-MCI groups was not significant, this finding is clinically insignificant (Fig 3). Conclusions:The predictive value and the involved regions of FDG-PET depend on disease phase and “A/T” status.