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[P4–224]: AXONAL DENSITY IS ASSOCIATED WITH SUBJECTIVE COGNITIVE DECLINE (SCD) IN OLDER ADULTS ASSESSED USING THE COGNITIVE CHANGE INDEX
Author(s) -
Wen Qiuting,
Mustafi Sourajit Mitra,
Harezlak Jaroslaw,
Risacher Shan L.,
West John D.,
Tallman Eileen F.,
Farlow Martin R.,
Unverzagt Frederick W.,
Apostolova Liana G.,
Saykin Andrew J.,
Wu YuChien
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2092
Subject(s) - cognitive decline , cognition , psychology , neuropsychology , analysis of variance , diffusion mri , audiology , clinical psychology , medicine , dementia , disease , neuroscience , magnetic resonance imaging , radiology
Figure 2. ROI map and scatter plot of CCI score and axonal density. A. The ROI in red denotes the right uncinate fasciculus. B. Axonal density negatively correlated with both CCI-12 (episodic memory) with p1⁄40.00009 and CCI-TOT (20 items) with p1⁄40.0002. Age, sex and education were adjusted in the linear regression analysis. Green dots denote cognitively normal (CN); blue dots denote subjective cognitive decline (SCD); red dots denote mild cognitive impairment (MCI); and the black solid line denotes the regression line. Qiuting Wen, Sourajit Mitra Mustafi, Jaroslaw Harezlak, Shannon L. Risacher, John D. West, Eileen F. Tallman, Martin R. Farlow, Frederick W. Unverzagt, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA; School of Public Health, Indiana University, Bloomington, IN, USA; Indiana University Network Science Institute, Bloomington, IN, USA. Contact e-mail: yucwu@iupui.edu