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[P4–216]: COMPARISON OF GRAY MATTER VOLUME AND FRACTIONAL ANISOTROPY IN MILD COGNITIVE IMPAIRMENT PATIENTS WITH AND WITHOUT AMYLOIDOPATHY
Author(s) -
Lee Suji,
Jeong HyunGhang,
Youn Hyun Chul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2084
Subject(s) - fractional anisotropy , diffusion mri , corpus callosum , dementia , pittsburgh compound b , cognitive impairment , voxel , voxel based morphometry , medicine , nuclear medicine , alzheimer's disease , pathology , psychology , cardiology , magnetic resonance imaging , white matter , radiology , disease
in the columnar cortical diffusionmeasurements were seen between Alzheimer’s and healthy aged participants with a diagnostic group classification accuracy of>95% (combined dataset of 81 subjects). The same measurements successfully categorised MCI participants who progressed to dementia within 2 years of scan, separately from stable MCI (20 subjects). Conclusions: These results indicate that cortical microstructure organisation in dementia is detectable using MRI of living subjects and may provide a marker of Alzheimer’s disease with high classification accuracy. These findings offer the prospect that future studies will be able to investigate the relationship between cognition and altered organisation of cerebral cortex microstructure, in vivo, in order to assess the damage to cellular networks as an index of disease progression. To significantly improve the lives of people with Alzheimer’s disease, an analysis method which improves early detection and differentiation of dementias has the potential to facilitate earlier and more effective care and to improve the success of drug trials.