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[P4–215]: NEW DIFFUSION IMAGING MEASUREMENTS OF CELLULAR ORGANISATION IN THE CORTEX IDENTIFY ALZHEIMER'S DISEASE AND PROGRESSIVE MCI
Author(s) -
Chance Steven A.,
Torso Mario,
Zamboni Giovanna,
Bozzali Marco,
Jenkinson Mark
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2083
Subject(s) - dementia , diffusion mri , cerebral cortex , cortex (anatomy) , alzheimer's disease , neuroscience , medicine , psychology , pathology , disease , magnetic resonance imaging , radiology
correlations with cognitive measures. The main regression analysis (see Methods section) was repeated twice, replacing p-tau/Ab42 with score on memory alteration test (M@T; Rami et al., 2007) and score on free recall of selective reminding test (Grober & Buschke, 1987), controlling for age, gender and level of education. Results were corrected for whole-brain multiple comparisons using identical methods to the main analysis. Top row left: significant positive correlations between EC and p-tau/Ab42; top row middle: significant negative correlations between EC and M@T scores; top row right: green voxels display regions where EC correlated significantly with both ptau/Ab42 and M@T scores. Bottom row left: significant negative correlation between EC and p-tau/Ab42; bottom row middle: significant positive (red) and significant negative (blue) correlations between EC and scores of free recall; bottom row right: green voxels display regions where EC correlated significantly with both p-tau/Ab42 and free recall scores. Poster Presentations: Wednesday, July 19, 2017 P1349