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[P4–213]: RELATIONSHIP BETWEEN CORPUS CALLOSUM VOLUME AND COGNITIVE FUNCTION IN MIDDLE‐AGED ADULTS
Author(s) -
Purokayastha Simran,
Ramesh Ranjini Garani,
Javali Mahendra,
Alladi Suvarna,
Rao Naren Prahalada
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2081
Subject(s) - stroop effect , corpus callosum , atrophy , splenium , psychology , executive dysfunction , boston naming test , neuropsychology , audiology , neuroimaging , magnetic resonance imaging , cognition , memory span , correlation , medicine , neuroscience , white matter , radiology , working memory , geometry , mathematics
Background: Tau accumulation is known to be core pathologic changes in various neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia (FTD). Recently, [F]AV-1451 (AV-1451) and [F]THK5351 (THK5351) have been developed to detect tau deposition in vivo. We determined whether amount and distribution of THK5351 and AV-1451 cortical uptakes differed between AD and FTD cases. We also examined whether THK5351 and AV-1451 tracers exhibited different amounts and distribution of off-target bindings. Methods:Eight participants underwent magnetic resonance image, Florbetaben (FBB) and tau PET a using two tracers, THK5351 and AV-1451. Case 1 and 2 were clinically diagnosed as AD such as early onset AD and logopenic variant primary progressive aphasia (lvPPA). Case 3, 4, 5 and 6 were clinically diagnosed as FTD such as semantic variant primary progressive aphasia (svPPA), non-fluent/agrammatic variant PPA (nfvPPA) and behavioral variant FTD (bvFTD). Case 7 and 8 were normal control (NC). Results: AV-1451 cortical uptakes were more prominent than THK5351 in Alzheimer disease, while, THK5351 cortical uptakes were more prominent in frontotemporal dementia, although THK5351 and AV-1451 tracers were highly correlated each other, (AD: r1⁄40.63, p1⁄40.009; FTD r1⁄40.69, p<0.001). Off target bindings of THK5351 uptakes were more prominent than AV-1451 uptakes with cortical uptakes of AV-1451 were more striking in AD, while cortical uptakes of THK5351 were more prominent in FTD. Both THK5351 and AV-1451 tracers, regardless of type of dementia, showed off-target bindings in the midbrain, basal ganglia and thalamus, but THK5351 seemed more noticeable with high correlation (r1⁄4 0.61 to 0.98). Conclusions:AD cases showed higher cortical uptakes of AV-1451 than those of THK5351 while FTD cases showed higher cortical uptakes of THK5351 than those of AV-1451. Off target regions such as the midbrain, thalamus, and basal ganglia showed more prominent uptakes of THK5351than those of AV1451 with wider variation of uptakes of THK5351. Our preliminary results suggested that AV-1451 seemed to be more sensitive and specific to Alzheimer disease type tau and less likely to present off-target binding.