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[P4–212]: HEAD‐TO‐HEAD COMPARISON OF [ 18 F] AV‐1451 AND [ 18 F] THK5351 FOR TAU IMAGING IN ALZHEIMER's DISEASE AND FRONTOTEMPORAL DEMENTIA
Author(s) -
Jang Young Kyoung,
Lyoo Chul Hyoung,
Rabinovici Gil D.,
Oh Seung Jun,
Cho Hanna,
Oh Minyoung,
Ryu Young Hoon,
Park Seongbeom,
Kim Hee Jin,
Moon Seung Hwan,
Jagust William J.,
Na Duk L.,
Kim Jae Seung,
Seo Sang Won
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2080
Subject(s) - medicine , frontotemporal dementia , primary progressive aphasia , frontotemporal lobar degeneration , dementia , semantic dementia , neuronal damage , disease , pathology , neuroscience , nuclear medicine , psychology , neuroprotection
Background:There is limited information on differences in resting state neural networks between early-onset Alzheimer’s disease (EOAD) phenotypic variants. This study distinguishes the non-amnestic phenotypes of EOAD from typical amnestic AD by mapping their weighted neuropsychological pattern onto resting state functional magnetic resonance imaging (rs-MRI) measures of functional connectivity. Methods: We examined functional magnetic resonance imaging (fMRI) connectivity in 14 patients with AD: 5 typical amnestic AD and 9 non-amnestic EOAD patients who were extensively diagnosed and characterized in terms of predominant presenting clinical symptoms. Resting state images were analyzed using Data Processing Assistant for Resting-State fMRI (DPARSFA) in Matlab and group averages and comparisons were made using SPM8. Between-group comparisons are shown at p<.005 uncorrected. The default mode network (DMN) resting state network (RSN) was created by correlating the time series from the posterior cingulate with the rest of the brain (Figure 1A). We interrogated right fronto-parietal connectivity using the right middle frontal gyrus as a seed region. Results:No betweengroup differences were observed in this small sample; however, the typical amnestic AD patients showed greater connectivity in frontal lobe relative to the non-amnestic EOAD patients in this RSN (Figure 1B). The region of the left inferior frontal gyrus showed reduced functional connectivity with bilateral temporal regions (Figure 1C). Typical amnestic AD also showed less connectivity between right hippocampus and bilateral hippocampi relative to non-amnestic EOAD patients (Fig 1D). Conclusions:Overall, this preliminary data suggests differential patterns of connectivity within RSNs in typical vs. non-amnestic presentations of Alzheimer’s disease. This pilot study suggests that the non-amnestic presentations tend to affect fronto-pareital networks more than those related to the hippocampi in typical AD. More work is ongoing to confirm and evaluate these preliminary findings.