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[P4–200]: INVESTIGATING THE PROGNOSIS OF TRANSIENT EPILEPTIC AMNESIA: DOES IT LEAD TO ALZHEIMER's DISEASE?
Author(s) -
Savage Sharon A.,
Butler Christopher R.,
Baker John,
Hodges John R.,
Zeman Adam Z.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2067
Subject(s) - forgetting , dementia , amnesia , neuropsychology , disease , medicine , epilepsy , cohort , episodic memory , psychology , neuropsychological assessment , pediatrics , cognition , psychiatry , cognitive psychology
22 control subjects were recruited. The patients’ demographic data were recorded and all subjects underwent a comprehensive assessment of neuropsychological function. Results:The mean age of carriers of low-range expansion allele was 74 years. Five carriers (71%) developed pakinsonian and/or cerebellar features. All carriers (100%) had abnormalMoCA and 3 of them (42%) had abnormalMMSE. The carrier group had significant lower mean MMSE score (24.57) and MOCA score (20.43) than control group (27.5 and 25.6 respectively). The carrier group performed significantly worse than the control group in Digit Symbol Test, Recognition Memory Test, Stroop Test, Trail Making Test and Clock Drawing Test. Conclusions:The study demonstrates that low-range expansion of TBP as low as 41 repeats appears to be pathogenic. It may be associated with a clinical onset at very advanced age, therefore, an overlap between disease and control in association with TBPrepeat expansion within this range was often observed by previous case-control cohorts.