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[P4–168]: THE FUNNEL STUDY: PRE‐SCREENING FOR MCI AND MILD AD PATIENTS FROM THE CHARIOT REGISTER
Author(s) -
Price Geraint J.,
Benjamin Maxwell J.,
Curry Lisa K.,
Smith Sabrina WL.,
Middleton Lefkos T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2035
Subject(s) - medicine , referral , clinical trial , montreal cognitive assessment , randomized controlled trial , protocol (science) , cognitive decline , observational study , psychological intervention , cognition , physical therapy , dementia , cognitive impairment , disease , psychiatry , family medicine , pathology , alternative medicine
is to examine patterns of apathy and agitation in a residential center, and their relation with general patterns of behavioral and psychological symptoms of dementia (BPSD) and with cognition. Methods: Residents of a nursing home-care facility in L ancara, Lugo(Spain) participated. Groups were created according to Clinical Dementia Rating (CDR) scores. From the total population of 195 residents assessed, 39 participants with CDR-2 (25 women, mean age1⁄483,S.D.1⁄48.10), 55 with CDR-3 (40 women, mean age1⁄4 85.84,S.D.1⁄47.31) and 80 with CRD-4 (63 women, mean age1⁄4 85.76,S.D.1⁄45.52) where selected. Apathy was assessed with the Apathy in Dementia–Nursery Home scale (APADEM-NH), and agitation was assessed with the Spanish version of the Cohen-Mansfield Agitation Inventory (CMAI), within a comprehensive assessment that also included the Neuro-Psychiatric Inventory (NPI), Cornell Scale for Depression in Dementia (CSDD), Spanish versions of the Mini-Mental State Examination (MMSE) and Severe MSSE (SMMSE). The psychopharmacological treatment was also recorded. Bivariate correlations and group comparisons were conducted using non-parametric tests. Results: Group differences were found according to the CDR groups for APADEM-NH (c1⁄469.13; df1⁄42;p<0.000) and CMAI scores (c1⁄423.61; df1⁄42;p<0.000), with higher levels of apathy and agitation in CDR-3. APADEM level obtained high negative correlations with MMSE (r1⁄4-0.80) and SMMSE (r1⁄4-0.79) scores, but did not reach significance in its correlations with NPI, CSDD and CMAI. CMAI obtained significant but low correlations with MMSE (r1⁄4-0.21) and SMMSE (r1⁄4-0.25), and high correlations with NPI (r1⁄40.58) and CSDD (r1⁄40.79) total scores. Significantly higher APADEM-NH and CMAI scores were associated with the intake of antipsychotics (Z1⁄4-2.28; df1⁄41; p<0.05 and Z1⁄4-1.85; df1⁄41; p<0.000, respectively) and sedatives (Z1⁄42.96; df1⁄41; p<0.05 and Z1⁄4-2.39; df1⁄41; p<0.05, respectively), and significantly higher APADEM-NH scores with the intake of cognitive enhancers (Z1⁄4-2.09; df1⁄41; p<0.05). Conclusions: Different patterns of apathy and agitation can be observed in a sample of dementia patients living in a nursing home. Further analyses are needed in order to classify the patients according to the BPSD observed and their use of drugs, and to explore implications for care.