[P1–134]: ENRICHMENT OF AMYLOID‐POSITIVE SAMPLES BY PET FROM EARLY SYMPTOMATIC AND PRODROMAL COHORT

cerebrospinal fluid; and (2) 36 young healthy subjects (mean age: 32.4 years 60.7 SE) before and after 1 night of sleep deprivation (SD) “challenge”. Immediately after the SD, they received a single psychostimulant (Modafinil) or placebo dose in a cross-over design. EEG/ERP markers were spectral power density at the standard delta, theta, alpha, beta, and gamma bands. ERP markers included the greatest positive peak (about +400 ms after target stimuli) in posterior electrodes (P3b peak). Cortical sources of the EEG/ERP markers were estimated by eLORETA freeware. Results: Cortical sources of delta rsEEG rhythms and theta-band ERPs were abnormal in MCI+ compared with MCIsubjects (p < 0.05 corrected). In Healthy subjects, the SD altered the cognitive performance as well as cortical sources of the P3b peak and delta/alpha EEG rhythms, while Modafinil partially recovered them. Conclusions: In Healthy subjects, the SD made EEG/ERP markers reminiscent of prodromal AD, while a psychostimulant (i.e. Modafinil) recovered them as a promising experimental “challenge” model for an early testing of novel symptomatic drugs antiAD in phase I clinical trials. These resting EEG and auditory ERP markers can be back-translated from prodromal AD patients to healthy young volunteers under a cognitive challenge.