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[P1–134]: ENRICHMENT OF AMYLOID‐POSITIVE SAMPLES BY PET FROM EARLY SYMPTOMATIC AND PRODROMAL COHORT
Author(s) -
Shoai Maryam,
Pither Richard,
Scopes Geoff,
EscottPrice Valentina,
Laws Simon M.,
Davis Julie,
Cleynen Isabelle,
Potier MarieClaude,
Bloor Claire,
Hampel Harald,
Vandenberghe Rik,
Hardy John
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.201
Subject(s) - genotyping , disease , oncology , biomarker , early onset alzheimer's disease , medicine , cohort , single nucleotide polymorphism , neuroimaging , genotype , alzheimer's disease , bioinformatics , genetics , biology , psychiatry , gene
cerebrospinal fluid; and (2) 36 young healthy subjects (mean age: 32.4 years 60.7 SE) before and after 1 night of sleep deprivation (SD) “challenge”. Immediately after the SD, they received a single psychostimulant (Modafinil) or placebo dose in a cross-over design. EEG/ERP markers were spectral power density at the standard delta, theta, alpha, beta, and gamma bands. ERP markers included the greatest positive peak (about +400 ms after target stimuli) in posterior electrodes (P3b peak). Cortical sources of the EEG/ERP markers were estimated by eLORETA freeware. Results: Cortical sources of delta rsEEG rhythms and theta-band ERPs were abnormal in MCI+ compared with MCIsubjects (p < 0.05 corrected). In Healthy subjects, the SD altered the cognitive performance as well as cortical sources of the P3b peak and delta/alpha EEG rhythms, while Modafinil partially recovered them. Conclusions: In Healthy subjects, the SD made EEG/ERP markers reminiscent of prodromal AD, while a psychostimulant (i.e. Modafinil) recovered them as a promising experimental “challenge” model for an early testing of novel symptomatic drugs antiAD in phase I clinical trials. These resting EEG and auditory ERP markers can be back-translated from prodromal AD patients to healthy young volunteers under a cognitive challenge.