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[P4–132]: A NEW COST‐EFFECTIVE METHOD FOR QUANTIFICATION OF TOTAL APOE IN HUMAN PLASMA SAMPLES
Author(s) -
Veiga Sergio,
Calero Olga,
RodríguezMartín Andrés,
GarcíaAlbert Luis,
Pérez Almudena,
Gassó Sergi,
Domínguez Mercedes,
Calero Miguel
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1998
Subject(s) - apolipoprotein e , biomarker , genotype , glycoprotein , human plasma , allele , chemistry , antibody , microbiology and biotechnology , chromatography , gene , disease , biochemistry , biology , immunology , medicine
(P < 0.05, P < 0.01). Serum TNF-a of Tibetans MCI group at HA is significantly higher when compared with those at MA (P < 0.05). Serum IL-1b in MCI of Hans was significantly higher at MA than at LA. Serum levels of IL-1b was correlated with MMSE score (r1⁄4–0.194, P<0.01) in the whole sample, while a negative correlation between serum concentrations of TNFa and ADAS-Cog scores was found in MCI patients (r1⁄40.745, P<0.01). Conclusions: The increase of TNF-a, IL-1b and IL-6 in those MCI and AD patients might be related to induction of the inflammatory suppression. Serum inflammatory factors were not significantly correlation between Hans and Tibetans patients in MCI and AD. These results imply that change of serum inflammatory factor levels of MCI and AD patients depends on altitude. The extent of hypoxia in inflammation might mediate severity of cognitive impairment.