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[P4–111]: POTENTIATION OF TAU PATHOLOGY BY THE APOEε4 DEMENTIA RISK ALLELE
Author(s) -
Jablonski Angela Marie,
Zhou Heather,
ParmentierBatteur Sophie,
Voleti Bhavya
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1977
Subject(s) - apolipoprotein e , neurodegeneration , allele , hyperphosphorylation , neurite , biology , neuroscience , microbiology and biotechnology , pathology , medicine , in vitro , genetics , disease , gene , kinase
Background:The cognitive reserve (CR) induced by factors such as education have been associated to a higher capability of individuals affected by Alzheimer’s disease (AD) to face the effects of neurodegeneration, thus resulting in a longer-lasting normal clinical appearance. We investigated the association between CR and tau deposition in healthy controls and mild-cognitively impaired (MCI) patients. Methods:Data were obtained from the ADNI database (www.loni.ucla.edu/ADNI). 113 patients received tau-PET imaging using 18F-AV-1451 and 3D T1 MP-RAGE MRI imaging. This preliminary analysis was performed on a subset of 22 subjects (age: 78.765.9, male/female: 13/9): 12 healthy controls (HC) and 10 late MCI (LMCI) patients. Each MRI image was registered to the Montreal Neurological Institute (MNI) T1 MRI brain template. For voxelwise statistical analyses in SPM 12 (Function Image Laboratory, Wellcome Department of Cognitive Neurology, London, UK), PET images were co-registered and spatially normalized to the subject’s MP-RAGE image, followed by smoothing using an 8 mm isotropic Gaussian kernel. SUVR images were calculated using the cerebellar crus as reference region. We used two multiple linear regression analyses in the entire sample to predict the interaction between cognitive status (expressed by the Mental State Examination (MMSE) score and tau deposition, and CR (expressed as the number of years of education) and tau deposition. MMSE score and years of education were considered as independent variables and tau deposition as dependent variable. The effect of age and MMSE score, or the number of years of study, were covaried out for all voxels. Findings meeting a height threshold of p< 0.001, uncorrected, were considered significant. Results:Asexpected, a significant negative correlation between tau binding and MMSE score was retrieved in the lateral temporal cortex, bilaterally, and in left frontal cortex. For education, a significant positive correlation was found in the superior temporal gyrus, bilaterally. We expect this result to be further confirmed by extending the analysis to the whole dataset. Conclusions: A positive correlation between higher tau deposition and education was shown in the superior temporal gyrus, bilaterally, suggesting that additional cognitive resources associated with years of education can compensate for a higher degree of pathology in this region.