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[P4–083]: A DOPAMINE RECEPTOR GENETIC VARIANT ENHANCES PERCEPTUAL SPEED IN COGNITIVELY HEALTHY SUBJECTS
Author(s) -
Barral Sandra,
Habeck Christian,
Gazes Elaine,
De Jager Philip L.,
Bennett David A.,
Stern Yaakov
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1948
Subject(s) - single nucleotide polymorphism , cognition , effects of sleep deprivation on cognitive performance , bonferroni correction , cohort , candidate gene , snp , episodic memory , psychology , genetics , biology , medicine , gene , neuroscience , genotype , statistics , mathematics
and a maximal 20-fold enrichment for one locus. Closest genes for the significant loci (conditional FDR 0.05) included CDC14C, HPR and RBMXP1. Conclusions:We identified polygenic overlap between cognitive impairment and a CRP phenotype in the HRS. Interpretation of the results is limited to cognitive impairment as non-AD causes of dementia are not differentiated. The variants and associated genes are involved in multiple pathological processes including metabolic, cardiovascular and immune response and are potentially important for AD risk prediction and development of novel therapeutic approaches based on anti-inflammatory mechanisms.