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[P1–124]: REGIONAL KINETIC MODELLING APPLICATION FOR TSPO PET TRACER [11C]PBR28
Author(s) -
Fan Zhen,
Dani Melanie,
Daniela Femminella Grazia,
Calsolaro Valeria,
Veronese Mattia,
Turkheimer Federico,
Gentleman Steve,
Hinz Rainer,
Edison Paul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.191
Subject(s) - translocator protein , tracer , positron emission tomography , binding potential , chemistry , brain tissue , compartment (ship) , nuclear medicine , biomedical engineering , pathology , medicine , physics , disease , oceanography , geology , nuclear physics , neuroinflammation
Background:Emerging evidences have demonstrated neuroinflammation has an important role in neurodegenerative disease. Second generation [11C]PBR28 PET has 80 fold affinity to TSPO compared to the previous tracers. Compared to kinetic models, the 3D parametric map enables simplified voxel-wise comparison between subjects or between regions. Here we evaluate for the first time the feasibility of generating [11C]PBR28 parametric map using spectral analysis, which may provide a better tracer binding differentiation as it account for the reversible and irreversible vascular component. We compared this with the Logan graphic analysis. Methods: 23 subjects (14MCI and 9HC) with TSPO high affinity binding were enrolled in this study. All subjects underwent T1/T2 weighted MRI and 90min [11C]PBR28 PET scans with arterial line. Spectral analysis was applied to evaluate the feasibility in generating various impulse response function (IRF) parametric maps at 1min, 30m, 45min, 60min, 75min and 90min. Graphic analysis was also applied to further evaluate the tracer signal and to compare with IRF parametric maps. Results:With arterial input function, spectrum identified three peaks: trapped tracer in plasma, and two tissue components. Among IRF(t) images with different time points, IRF(90min) parametric maps revealed the lowest noise. For the Logan graphic analysis, the [11C]PBR28 IRF(90min) parametric maps were generated using dynamic image for 6 data points (30w90mins), which showed a good correlation with Logan graphic analysis (r1⁄40.9285, p1⁄40.0001). Conclusions: In this study, for the first time, we have demonstrated that the spectral analysis could generate [11C]PBR28 parametric map, which showed consistency with Logan graphic analysis in frontal, temporal, parietal, occipital lobe, medial temporal lobe, hippocampus and thalamus. This demonstrate that the spectral analysis could be used to create [11C]PBR28 PET parametric maps which allows voxel-level comparison between regions and between subjects.