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[P4–032]: BILIVERDIN REDUCTASE‐A MEDIATES THE BENEFICIAL EFFECTS OF INTRANASAL INSULIN ADMINISTRATION ON AD PATHOLOGY IN THE BRAIN OF 3XTG‐AD MICE
Author(s) -
Barone Eugenio,
Triani Francesca,
Tramutola Antonella,
Di Domenico Fabio,
Cassano Tommaso,
Butterfield D Allan,
Perluigi Marzia
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1896
Subject(s) - pi3k/akt/mtor pathway , insulin receptor , protein kinase b , insulin , nasal administration , signal transduction , hippocampus , medicine , morris water navigation task , stimulation , endocrinology , insulin resistance , chemistry , pharmacology , biochemistry
cortex (Fig. 1). Conclusions:We have shown Sp1 is an AD-relevant TF with a significant SNP near its gene. From TF activation profiling, we observed several potential TFs that may also affect the amyloid pathway. We continue to investigate the relationship between genetic variants in TFs and AD-related endophenotypes as well as how these changes can be targeted by TF-modulating drugs as a possible strategy in treatment of AD. Supported by grants fromNIH/NIA R01AG051086-01, IADC-Core and ISDH-13609 to DKL.