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[P4–031]: ALZHEIMER'S DISEASE AS A DISORDER OF TRYPTOPHAN METABOLISM
Author(s) -
Weaver Donald F.,
Meek Autumn,
Barden Christopher,
Reed Mark,
Taylor Marcia,
Wang Yanfei,
Brant Michael,
Stafford Paul,
Kelly Brendan,
Diez Elena Cecilia
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1895
Subject(s) - enzyme , chemistry , indole test , biochemistry , computational biology , biology
cortex (Fig. 1). Conclusions:We have shown Sp1 is an AD-relevant TF with a significant SNP near its gene. From TF activation profiling, we observed several potential TFs that may also affect the amyloid pathway. We continue to investigate the relationship between genetic variants in TFs and AD-related endophenotypes as well as how these changes can be targeted by TF-modulating drugs as a possible strategy in treatment of AD. Supported by grants fromNIH/NIA R01AG051086-01, IADC-Core and ISDH-13609 to DKL.