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[P1–121]: ABILITY OF FRAGMENTS FROM RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS TO PREVENT MEMORY LOSS CORRELATES WITH IMPROVEMENT OF MORPHO‐FUNCTIONAL STATE OF NEURONS IN ANIMALS WITH ALZHEIMER's‐LIKE NEURODEGENERATION
Author(s) -
Balasanyants S.M.,
Volkova T.D.,
Kamynina A.V.,
Koroev D.O.,
Aleksandrova I.J.,
Nesterova I.V.,
Samokhin A.N.,
Bobkova N.V.,
Volpina O.M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.188
Subject(s) - rage (emotion) , glycation , neurodegeneration , receptor , hippocampus , chemistry , alzheimer's disease , morris water navigation task , peptide , oxidative stress , medicine , endocrinology , neuroscience , pharmacology , biology , biochemistry , disease
amyloid b, a-synuclein, prion and tau. The models were further validated against experimental NMR, small-angle scattering (SAS) data and other available experimental observables by back-calculation of these observables from simulation data. Results: Our results indicate that the methods which give larger weight to the protein-water interactions generally give a better match with experimental data on neurodegenerative IDPs, in terms of both protein sizes and also dynamics, which gives a substantial improvement over the most commonly used protein/water models. Conclusions:Most standard methods tend to underestimate the protein-water interactions for IDPs in general, and show discrepancy with experimental results. Recently, two ‘IDP-friendly’ protein (Amber ff03WS) and water (TIP4P-D) models were introduced. To our knowledge, these newer methods were not previously benchmarked across a broad range of neurodegenerative (amyloidogenic) IDP monomers. Our analysis shows that these newer methods perform significantly better than the commonly used ones when it comes to correlation with experiments, and provide a potentially predictive model for properties of new and as yet poorly characterised IDPs.