Premium
[P4–012]: HOW DO PEOPLE WITH MILD COGNITIVE IMPAIRMENT AND THEIR FAMILY MEMBERS DECIDE WHETHER TO ENROLL IN PRODROMAL ALZHEIMER's DISEASE CLINICAL TRIALS?
Author(s) -
Cox Chelsea G.,
Gillen Daniel L.,
Grill Joshua D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1876
Subject(s) - clinical trial , biomarker , dementia , disease , psychology , medicine , cognition , cognitive impairment , clinical psychology , psychiatry , biochemistry , chemistry
(MCI)/Dementia or SLUMS), and mood (BDI-II), were collected before, at midpoint, and after 8 weeks. Results:According to paired samples t-tests conducted between baseline and endpoint for the MMSE, SLUMS and BDI-II, baseline mean scores significantly improved by endpoint for all three measures: {tMMSE(16)1⁄4-4.88, p1⁄4.00: Mbaseline1⁄423.88 (SD1⁄45.02), Mendpoint1⁄426.82 (SD1⁄43.43); tSLUMS(9)1⁄4-4.52, p<.001: Mbaseline1⁄421.40(SD1⁄44.27), Mendpoint1⁄4 26.30(SD1⁄43.49); tBDI-II(16)1⁄42.22, p<.05: Mbaseline1⁄414.29 (SD1⁄411.07), Mendpoint1⁄411.06(SD1⁄49.59)}. Regarding cognition scores, 8 subjects transitioned from MCI range to Normal, and 1 subject transitioned from Dementia to MCI. Linear regression analysis indicated a trend for significance for the baseline SLUMS, predicting 36% of the variance in depression outcome: for every 1 unit increase in SLUMS, there was a 1.3 unit decrease in depression severity. Conclusions: Eight weeks of EE-cycling significantly improves cognition and mood in a dementia-prone population of older adults coached for activation. This suggests potential for a new care standard and coaching approach for adults/seniors at risk for dementia, and strongly supports EE’s role in dementia prevention and MCI treatment. To confirm these findings, controlled studies with larger samples are warranted.