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[P3–050]: ANTI‐INFLAMMATORY EFFECT OF TSPO LIGAND IN MOUSE MODEL OF TAUOPATHY
Author(s) -
Barron Anna M.,
Ji Bin,
Sahara Naruhiko,
Zhang MingRong,
Suhara Tetsuya,
Higuchi Makoto
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1863
Subject(s) - translocator protein , tauopathy , neuroinflammation , microglia , inflammation , genetically modified mouse , neuroprotection , neuroscience , transgene , pathogenesis , medicine , tau protein , pathology , psychology , biology , alzheimer's disease , immunology , neurodegeneration , disease , biochemistry , gene
dapagliflozin or vildagliptin equally improved brain mitochondrial function, brain insulin sensitivity and prevented cognitive decline. However, only dapagliflozin improved hippocampal synaptic plasticity. Surprisingly, combined drugs exerted greater efficacy in increased brain insulin sensitivity than monotherapy. All findings were concluded in table 1. Conclusions:Both vildagliptin and dapaglifozin share similar efficacy on improving brain mitochondrial function, brain insulin sensitivity and preventing cognitive decline in obese-insulin resistant rats. However, dapaglifozin exert better efficacy on the improvement of metabolic profiles and hippocampal synaptic plasticity than vildagliptin.