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[P3–039]: PROPHYLACTIC NEUROPROTECTIVE EFFICACY OF SELAGINELLA (SANJEEVANI) FLAVONOIDS AGAINST LIPOPOLYSACCHARIDE‐INDUCED NEURODEGENERATION IN DROSOPHILA AND MICE: RELEVANCE TO ALZHEIMER's DISEASE THERAPY
Author(s) -
Chandran Girish,
Sugur Kavya,
Chauhan Jyoti Bala,
M Muralidhara
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1852
Subject(s) - oxidative stress , neuroprotection , pharmacology , aché , neurodegeneration , lipopolysaccharide , medicine , cholinesterase , morris water navigation task , acetylcholinesterase , hippocampus , biology , biochemistry , disease , enzyme
inhibition of LTP in a dose-dependent manner. Finally, we examined if systemic passive immunization could prevent or reverse the persistent inhibition of LTP measured in vivo 7 days after a single i.c.v. injection of synthetic Aß42. A single systemic injection of MEDI1814, given either prior to i.c.v. treatement with Aß on day 1, or prior to recording synaptic plasticity on day 7, prevented the disruption of LTP. In contrast, neither prenor post-Aß treatment with the control antibody was effective. Conclusions: Intracerebral or systemic administration of a high affinity monoclonal antibody directed to the C-terminus of Aß42 rapidly prevents or reverses synaptic plasticity impairment in the rat hippocampus caused by synthetic or human AD brainderived Ab aggregates.