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[P3–010]: LEVETIRACETAM ALTERS OSCILLATORY CONNECTIVITY IN ALZHEIMER's DISEASE
Author(s) -
Press Daniel Z.,
Musaeus Christian,
Shafi Mouhsin,
Santarnecchi Emiliano,
Herman Susan T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1823
Subject(s) - levetiracetam , subclinical infection , electroencephalography , coherence (philosophical gambling strategy) , placebo , medicine , psychology , audiology , epilepsy , psychiatry , physics , pathology , alternative medicine , quantum mechanics
Background: IGF-1 is a putative mechanism to the effects of exercise on cognition and studies have shown a resistance to IGF-1 in AD. The aim of this study was to compare the acute response to an aerobic exercise session in non-dement elderly and elderly with AD in IGF-1 levels. We also wanted to verify the chronic effects of exercise on IGF-1 levels and cognition in AD elderly. Methods: Forty non-dement elderly, [age: 74,164,61 years; Mini Mental State Examination (MMSE) median score: 28,5 points; average schooling years: 4 years]; and 34 elderly with AD, (age: 75,9 6 6,5 years; MMSE median score: 21 points; average schooling years: 4 years) were included in the study. In order to compare the IGF-1 levels after an aerobic training session, both groups did an incremental test on a treadmill. Elderly with AD were assigned to compose a Training group (TG) and a Control group (CG). The TG underwent 25-40 minutes aerobic training session on treadmill in moderate intensity, 3 times per week for 12 weeks. The CG maintained their routine. Questionnaires were applied for assessment of cognitive functions and blood samples were collected after aerobic session (non-dement elderly/ elderly with AD) and after the 12-week aerobic exercise training (TG/ CG) to measure IGF-1 levels. Results: Comparing non-dement elderly with elderly with AD, baseline IGF-1 levels showed a tendency to difference and the response for aerobic session was significantly different. The elderly with AD had lower basal IGF-1 levels than non-dement elderly (p1⁄40,08). Besides, the elderly with AD showed an increment in IGF-1 levels after the aerobic exercise session, while non-dement elderly had a decrease (p1⁄40,01). Considering the chronic effects, after 12 weeks of training, no differences between TG and CG were found in IGF-1 levels or in cognition parameters. Conclusions:non-dement elderly and elderly with AD have different response in IGF-1 levels after an acute aerobic exercise session. This response can indicate an IGF-1 resistance in AD elderly. The aerobic training did not have significantly effects on IGF-1 and cognition. The training duration (12 weeks) was not enough to improve cognition.