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[P3–593]: SEX DIFFERENCES IN THE PSYCHOPHYSICAL RESPONSE TO CONTACT HEAT IN ALZHEIMER's DISEASE
Author(s) -
Atalla Sebastian W.,
Anthony Robert S.,
Dietrich Mary S.,
Cowan Ronald L.,
Monroe Todd B.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1813
Subject(s) - disease , audiology , threshold of pain , medicine , population , psychology , physical therapy , environmental health
OAs (n1⁄41795) received CDR ratings, and a subset (n1⁄4591) had CSF biomarker measurements. Cox proportional hazards models and Kaplan-Meier survival curves were used to analyze differences in CDR and biomarker groups as predictors of time to driving cessation. Results: Participants with higher CDR scores and more abnormal biomarker measurements had a shorter time to driving cessation. After adjusting for multiple comparisons, there was a statistically significant difference in time to driving cessation between CDR 0 and CDR 0.5 (p<.0001) participants, between CDR 0 and CDR 1 (p<.0001) participants, and between CDR 0.5 and CDR 1 (p1⁄40.005) participants. In the Cox proportional hazards model testing the effect of tau/Ab42, only the effect of the biomarker ratio (HR1⁄42.04; 95% CI1⁄41.28-3.22; p<0.003), age (HR1⁄41.08; 95% CI1⁄41.04-1.11; p<.0001), and CDR (CDR 0.5 vs. 0: HR1⁄43.44, 95% CI1⁄42.10-5.63; CDR 1 vs. 0: HR1⁄45.80, 95% CI1⁄42.59-12.99; p<0.001) had a significant effect on driving cessation. Similar results were found when testing the effects of ptau/Ab42. Conclusions:While preclinical AD does not appear to have a measurable cognitive impact, it is not benign, as it seems to have an impact on complex activities like driving. Higher levels of AD biomarkers, including in preclinical AD, and higher CDR scores, lead to earlier driving cessation. Negative functional outcomes of preclinical AD show a non-benign phase of the disease.