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[P3–572]: MULTIMODAL LIFESTYLE AND NUTRITIONAL INTERVENTION IN PRODROMAL ALZHEIMER's DISEASE: MIND‐AD MINI PILOT TRIAL
Author(s) -
Thunborg Charlotta,
Sindi Shireen,
Faxen Gerd,
Storskog Thomas,
Soininen Hilkka,
Hartmann Tobias,
Andrieu Sandrine,
Solomon Alina,
Kivipelto Miia
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1792
Subject(s) - medicine , randomized controlled trial , intervention (counseling) , psychological intervention , disease , population , physical therapy , quality of life (healthcare) , gerontology , cognition , psychiatry , environmental health , nursing
of diabetes mellitus. A single measure of adherence was derived by factor analysis of multiple individual behaviors suggested by the guidelines. The Cox proportional hazard model was used for the analysis. Results: Of 3797 individuals, 513 (13.5%) were diagnosed with AD over the study period. After adjusting for age, adherence to T2D screening guidelines was found to reduce the risk of AD by 20-24% depending on the specification of the adherence measure. Sensitivity analysis showed that this result was stable. Other significant effects on the risk of AD was observed for college or higher level education [Hazard Ratio (HR):0.65; p-val:0.023], stroke [HR:1.40; p-val: 0.013], having four or more limitations in 10-point physical functioning index [HR:1.33; p-val:0.008], and a diagnosis of other dementias [HR:12.94; p-val:<0.001]. The last result is expected as mixed dementia is an increasingly prevalent phenomenon. Main study results are stable when this explanatory variable is excluded. Conclusions:Adherence to screening guidelines substantially reduces the risk of AD in a population of elderly with T2D. We conclude that onset of AD can be offset through timely health-conscious behavior. Possible mechanisms may include earlier start of interventions aiming to reduce blood glucose levels and improve insulin sensitivity.