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[P3–571]: THE EFFECT OF ADHERENCE TO SCREENING GUIDELINES ON THE RISK OF ALZHEIMER's DISEASE IN ELDERLY INDIVIDUALS NEWLY DIAGNOSED WITH DIABETES MELLITUS
Author(s) -
Yashkin Arseniy Pavlovich,
Akushevich Igor,
Ukraintseva Svetlana,
Yashin Anatoliy I.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1791
Subject(s) - medicine , hazard ratio , diabetes mellitus , disease , incidence (geometry) , proportional hazards model , type 2 diabetes mellitus , epidemiology , type 2 diabetes , alzheimer's disease , gerontology , confidence interval , endocrinology , physics , optics
Objective: The aim of this study was to examine the possibility that type 2 diabetes and Alzheimer’s disease may share common behavioral protective factors such as adherence to type 2 diabetes treatment guidelines given that these two diseases have both epidemiological and metabolic similarities. Method: The method used in this study is a retrospective cohort study of 3,797 U.S. Medicare fee-for-service beneficiaries aged 66+ newly diagnosed with type 2 diabetes and without a prior record of Alzheimer’s disease based on the Health and Retirement Study. Results: Results of a left-truncated Cox model showed that adherence reduces the risk of Alzheimer’s disease by 20% to 24%. Other significant effects were college education (hazard ratio [HR]: 0.65; p value: .023), stroke (HR: 1.40; p value: .013), and 4+ limitations in physical functioning (HR: 1.33; p value: .008). Discussion: Risk of Alzheimer’s disease can be reduced by behavioral factors. Possible mechanisms may include earlier start of interventions to reduce blood glucose levels and improve insulin sensitivity.