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[P3–543]: ASSOCIATION OF PSYCHOSOCIAL WORK STRESS WITH COGNITIVE DECLINE AND BRAIN STRUCTURE DIFFERENCES
Author(s) -
Pan KuanYu,
Xu Weili,
Mangialsche Francesca,
Kalpouzos Gregoria,
Bäckman Lars,
Fratiglioni Laura,
Wang HuiXin
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1763
Subject(s) - job strain , psychosocial , job control , cognitive decline , cognition , cohort , medicine , population , cohort study , gerontology , psychology , dementia , psychiatry , work (physics) , environmental health , mechanical engineering , disease , engineering
CINAHLwere searched for all publications until 8 January 2016. Articleswere included if the fulfilled the inclusion criteria: (1)myocardial infarction, angina pectoris or coronary heart disease (combination of both) as predictor variable; (2) cognition, cognitive impairment or dementia as outcome; (3) population-based study; (4) prospective ( 1 year follow-up), cross-sectional or case-control study design; (5) 100 participants; and (6) aged 45 years. Two reviewers independently screened all abstracts and extracted information from potential relevant full-text articles. We pooled estimates from the most fully adjusted model using random-effects meta-analysis. Results:We identified 6,132 abstracts, of which 24 studies were included. Ameta-analysis of 10prospective cohort studies showed that coronaryheart disease was associatedwith increased riskof cognitive impairment or dementia (OR1⁄4 1.45, 95%CI1⁄4 1.21-1.74, p<0.001). Between-study heterogeneity was low (I1⁄4 25.7%, 95%CI1⁄4 0-64, p1⁄4 0.207). Similar significant associations were found in separate meta-analyses of prospective cohort studies for the individual predictors (myocardial infarction, angina pectoris). In contrast, meta-analyses of cross-sectional and case-control studieswere inconclusive.Conclusions:Thismeta-analysis suggests that coronary heart disease is prospectively associated with increased odds of developing cognitive impairment or dementia.Given the projected worldwide increase in the number of people affected by coronaryheart disease anddementia, insight into causalmechanismsor common pathways underlying the heart-brain connection is needed.