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[P3–538]: LOW‐GRADE INFLAMMATION: HIGH SENSITIVITY C‐REACTIVE PROTEIN INVERSELY ASSOCIATED WITH INCIDENT ALZHEIMER DISEASE IN CASES 60 YEARS AND OLDER: THE HUNT STUDY, NORWAY
Author(s) -
Gabin Jessica
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1758
Subject(s) - medicine , epidemiology , c reactive protein , logistic regression , disease , inflammation , odds ratio , immunosenescence , alzheimer's disease , immunology , immune system
death, and>90 day gaps in health plan coverage. Results:Themean age at baseline was 71.0 years (range 60–102), with 54.7% female, 68% White, 6% Black, 7% Latino, 9% Asian. Seven percent (35,961) were diagnosed with anxiety-only, 4% (18,361) with depression-only, and 5% (24,569) with co-occurring anxietydepression. Nearly 12% (59,127) were diagnosed with dementia over 13 years of follow-up. Age-adjusted incidence rates were highest among those with depression-only (20.7/1,000 person-years) and co-occurring anxiety-depression (20.6/1,000 person-years) and lower for those with anxiety-only (16.3/1,000 person-years). Hazard ratios adjusted for age, sex, race/ethnicity, and chronic conditions (relative to those without anxiety and depression) were 1.23 (95% CI1⁄41.19-1.26) for those with anxiety-only, 1.80 (95% CI1⁄41.73-1.86) for those with depression-only, and 1.85 (95% CI1⁄41.79-1.91) for those with anxiety-depression. Conclusions:Our results suggest that co-occurring anxiety-depression is associated with a higher risk of dementia in a large population-based sample of healthcaremembers over 13 years. Future studies aimed at understanding disparities inmental health in later life and themechanisms linking anxiety-depression with risk of dementia are needed. Public health efforts should focus on screening and improving treatment outcomes in older populations with comorbid anxiety-depression.