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[P1–108]: SYSTEMS PHARMACOLOGY ANALYSIS OF THE Aβ OLIGOMER RESPONSE FOLLOWING BACE1 INHIBITION: EVIDENCE FOR SECOND‐ORDER Aβ42 OLIGOMERIZATION
Author(s) -
Maanen Eline M.T.,
Steeg Tamara J.,
Kalinina Juliya,
Stone Julie,
Michener Maria S.,
Savage Mary J.,
Kennedy Matthew,
Parker Eric,
Danhof Meindert
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.175
Subject(s) - neurodegeneration , pharmacology , chemistry , oligomer , biomarker , neuroscience , biochemistry , biology , disease , medicine , organic chemistry
food and water intakewere repeatedly measured in triple transgenic mice of Alzheimer’s disease (3xTg AD mice) and non-transgenic control mice from 4 to 40 week-old. Metabolic rate and physical activity data was obtained via indirect calorimetry. Mice were then sacrificed for immunohistochemistry on amyloid pathology. Results: 3xTg AD female mice weighs lighter at 4 week-old but gain weight at a faster pace and weigh heavier than non-Tg control mice at 40 week-old. A higher intake amount and lower physical activity was noted in 3xTg AD female mice. Body weight and amount of food intakewere found to bewell correlated with number of amyloid stained positive cells and pyknotic cells in amygdala (r1⁄4 0.86, 0.88 respectively). Conclusions:This study demonstrated a gradual weight gain process in 3xTg AD female mice and is possibly attributed to relative hyperphagia and lower physical activity. This body weight alteration and hyperphagia behavior may be associated with amygdala pathology.