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[P3–467]: REPETITIVE NEGATIVE THINKING IS ASSOCIATED WITH AMYLOID BURDEN: EMPIRICAL SUPPORT FOR THE COGNITIVE DEBT HYPOTHESIS
Author(s) -
Marchant Natalie L.,
ArenazaUrquijo Eider M.,
Chetelat Gael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1685
Subject(s) - clinical dementia rating , anxiety , psychology , apolipoprotein e , clinical psychology , depression (economics) , cognition , dementia , medicine , disease , psychiatry , cognitive impairment , economics , macroeconomics
Background:Subjective cognitive complaints (SCC) and mediotemporal atrophy are potential markers of earlyAlzheimer’s disease (AD). The aim of this study was to assess the relationship among hippocampal volumes and perirhinal cortical thickness and specific SCC; and to compare it to a standard, routinely used memory tests in non demented older adults. Methods:Eighty one non-demented older adults (22 with amnestic mild cognitive impairment (MCI), 7 with non-amnestic MCI and 52 cognitively healthy older adults) underwent comprehensive neuropsychological testing and 1.5T MRI with volumetry using FreeSurfer 5.3. to measure estimated total intracranial volume (eTIV), adjusted right and left hippocampal volume (RHV, LHV), and left and right perirhinal cortical thickness (LPT, RPT). A 10-item yes/no SCC questionnaire was administered to inquire about SCC during recent 6 months. Spearman’s correlation was used to correct for non-normal score distribution. Subjects with significant vascular changes (Fazekas score >1) and depression (>5 on 15 item Geriatric depression scale) were excluded. Results:We observed correlations of both hippocampi and RPT with “Difficulties with recalling past events” (rRHV1⁄4.-29, rLHV1⁄4-.33 and rPRT1⁄4-.27), “Feeling of memory change” (rRHV1⁄4-.24 and rLHV1⁄4-.23) items, and with the total SCC score (rRHV1⁄4-.19 and rLHV1⁄4-.23). LHVand RPT correlated with “Worse memory in comparison to peers” (rLHV1⁄4-.19, rRHT1⁄4-.21) and LHV with “Subjective limitation in daily activities” (rLHV1⁄4-.23) items. “Losing things“ correlated with bilateral perirhinal thickness (rRLT 1⁄4 -.27 and rRPT1⁄4-.34). Auditory Verbal Learning Test––learning (sum of trials 1 to 5) and delayed recall correlated with LHV (both rs1⁄4.19) and AVLT 1-5 correlated with RPT (r1⁄4.24). MMSE correlated with bilateral perirhinal thickness (r1⁄4 .28 and .46 respectively). All ps’ were <.05. We did not find correlation between any SCC item or any memory score and eTIV. Conclusions:Specific SCC reflect mediotemporal atrophy as well as standard memory tests in non demented older adults and can aid diagnostics of early AD.