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[P3–465]: PROGRESSION OF VISUAL FIELDS IN POSTERIOR CORTICAL ATROPHY MIRRORS THAT OF COGNITIVE DEFICITS
Author(s) -
Maia da Silva Mari N.,
Galton Merle,
Plant Gordon T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1683
Subject(s) - cognition , audiology , visual field , spelling , posterior cortical atrophy , perception , psychology , atrophy , medicine , ophthalmology , neuroscience , dementia , linguistics , philosophy , disease
.023). In addition, naMCI exhibited significantly higher hardswitching score on letter fluency task compared to aMCI (t(57) 1⁄4 -2.21, p 1⁄4 .033). In terms of functional neuroanatomical substrates, mean cluster size on the semantic fluency task was negatively associated with regional cerebral glucose metabolism (rCMglc) in the left middle frontal gyrus, and hard-switching score on letter fluency was positively associated with rCMglc in the left middle and inferior frontal gyrus. Conclusions: The findings suggest that aMCI patients perform verbal fluency task in more efficient manner compared to non-amnestic counterparts despite the same level of overall performance and that such efficiency is associated with functional state of the middle and inferior prefrontal cortices.