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[P3–449]: THE CONTRIBUTION OF HYPERPHOSPHORYLATED‐TAU PATHOLOGY TO NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER's DISEASE
Author(s) -
Ehrenberg Alexander J.,
Suemoto Claudia K.,
Petersen Cathrine,
Kramer Joel H.,
Eser Rana April,
Alho Ana T.,
Paraizo Leite Renata Elaine,
Diehl Rodriguez Roberta,
Farfel Jose M.,
Eloah de Lucena FerrettiRebustini Renata,
Nascimento Camila F.,
Nitrini Ricardo,
Pasquallucci Carlos Augusto,
JacobFilho Wilson,
Miller Bruce L.,
Grinberg Lea T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1667
Subject(s) - locus coeruleus , apathy , dementia , psychology , locus ceruleus , disease , alzheimer's disease , neurofibrillary tangle , neuroscience , psychiatry , medicine , pathology , parkinson's disease , substantia nigra , senile plaques , cognition , central nervous system
immigrants. Methods: 49 Moroccan, Turkish and Cape Verdean patients with diverse cognitive complaints visited the multicultural memory clinic of the Alzheimer Center Rotterdam, TheNetherlands. 35% of the patients were illiterate; 71% did not complete primary education. An adapted test protocol including the Cross Cultural Dementia screening test (CCDz) was used, as well as Dutch neuropsychological tests that are considered cross-culturally applicable. A medical interpreter translated the test instructions. Results: Nearly all patients could complete the recognition memory task of the CCD, a test that is not timed and contains culture-sensitive photographs. 24% of patients were unable to finish the CCD’s timed task involving dot counting (similar to TMT A); 60% of all patients were unable to complete the combined counting/switching task. Most of the other cognitive tests required too many scholastic skills and abstract reasoning (e.g. figure copy, digit span, BADS key search test) andwere therefore not even attemptedwithmany patients. Qualitative analysis of the results revealed difficulties in recognizing line drawings (e.g. visual-associative memory), drawing linear designs and processing depth cues. Similarly, tests relying heavily on verbal responses and vocabulary (such as naming tasks, verbal memory, orientation questions) often were not administered. Conclusions: In the memory clinic, neuropsychological assessments requiring basic scholastic skills, involving line drawings and relying heavily on language/vocabulary are unfit for use in linguistically and culturally diverse populations. Adapting stimuli to include life-like material (e.g. photographs)might be promising.Our future researchwill focus on the development of cross-cultural testsmeasuring all cognitive domains. z Goudsmit et al. 2016 J Clin Exp Neuropsychol.