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[P3–426]: TISSUE MICROARRAY AND QUANTITATIVE NEUROPATHOLOGY: A HIGH THROUGHPUT METHODOLOGY FOR NEUROPATHOLOGICAL ASSESSMENT OF LARGE SCALE COHORTS
Author(s) -
Walker Lauren,
McAleese Kirsty E.,
Johnson Mary,
Khundakar Ahmad A.,
Erskine Daniel,
Thomas Alan,
McKeith Ian G.,
Attems Johannes
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1643
Subject(s) - neuropathology , pathology , entorhinal cortex , pathological , interquartile range , medicine , dementia , alzheimer's disease , biology , disease , hippocampal formation
Figure 1. boxplots of MHC Class II, and C4b. These boxplots show the distribution MHC Class II and C4b over the temporal and parietal cortex per AD phenotype. Contrary to typical AD, the atypical AD group has more immunoreactivity for antigen presenting microglia (MHC Class II) and complement factor C4b (C4b) in the parietal than the temporal cortex. Lauren Walker, Kirsty E. McAleese, Mary Johnson, Ahmad A. Khundakar, Daniel Erskine, Alan Thomas, Ian G. McKeith, Johannes Attems, Newcastle University, Newcastle upon Tyne, United Kingdom. Contact e-mail: lauren.walker1@newcastle.ac.uk