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[P3–416]: PROFILE OF INTRACELLULAR CHOLESTEROL TRAFFICKING IN POSTMORTEM BRAINS OF DOWN SYNDROME AND ALZHEIMER DISEASE
Author(s) -
Arenas Rios Fabian O.,
DiazMarugan Laura,
RodriguezPeiris Maria,
GarciaRuiz Carmen,
FernandezCheca Jose Carlos
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1633
Subject(s) - neurodegeneration , intracellular , alzheimer's disease , biology , cholesterol , endocrinology , medicine , neuroscience , pathology , disease , microbiology and biotechnology
sample of cognitively normal elderly. The interactive effect of SDB*APOE4 on amyloid burdenwas also examined.Methods:Data usedwere obtained from the ADNI database (adni.loni.usc.edu). Study participants included a total of 516 cognitively normal subjects and were a subset of the ADNI cohort. SDB was self-reported and participants were labeled SDB+, or SDB . Brain Ab-42 levels were determined at baseline and follow-upvisits.Multi-levelmixed effects linear regression models were used to examine the relationship between SDB and Ab-42 volumes. First, we fit a linear regression model for each participant separately at each time point, and second, we regressed unknown time-specific regression coefficients against time. Our models were adjusted for sex, and body mass index. There was no difference between OSA groups for APOE e4 status, age and history of cardiovascular disease. The interactive effect of SDB*APOE4 on amyloid burden was also examined.Results:There was significant variation between subjects in mean Ab-42 volumes at baseline (intercept) (mean SUVR; B 1⁄4 0.006, p < .0001), as well as significant variation in the change in Ab-42 volumes over time (slope) (mean SUVR; B1⁄4 0.006, p< .0001). The covariance between the baseline Ab-42 level and Ab42 volume change over time indicated that SDB subjects experienced a faster increase in brain Ab-42 volumes over time (p < .0001). The interactive effect of SDB*APOE4 on amyloid burden was not significant. Conclusions: Among community-dwelling cognitively normal older adults, SDB is associatedwith greater b-amyloid burden changes over time regardless of APOE4 status. This suggests that clinical interventions aimed at SDB, such as treatment with CPAP or dental appliances, implemented during the early phase in which tissue damage precedes clinical symptoms and neuronal dysfunction, may mitigate the progression of cognitive impairment.