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[P3–413]: CLINICAL EFFECT OF SMALL‐VESSEL DISEASE AND WHITE MATTER NETWORK ON DEPRESSION IN PATIENTS WITH COGNITIVE IMPAIRMENT
Author(s) -
Kim Yeshin,
Jang Hyemin,
Kim Ko Woon,
San Lee Jin,
Jang Young Kyoung,
Kim Sung Tae,
Kim Hee Jin,
Na Duk L.,
Seo Sang Won
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1630
Subject(s) - hyperintensity , white matter , psychology , depression (economics) , cardiology , geriatric depression scale , diffusion mri , medicine , neuroscience , cognition , magnetic resonance imaging , depressive symptoms , radiology , economics , macroeconomics
grey matter density at every voxel. The images were false discovery rate corrected at 0.01. We further carried out an analysis of variance to compare the synergistic model with the independent and additive models. Results: We found that the synergism between, rather than the independent or additive effects of, amyloid-b and tau pathologies in the precuneus, posterior cingulate, inferior parietal, lateral temporal andmedial prefrontal corticeswas associatedwithworse clinical status in the predementia phase ofAD (Fig.1). In addition, an analysis of variance strongly supported that the model with the interaction term best described the cognitive status, as compared to models testing only amyloid-b, only tau, and amyloid-b plus tau with a P<0.0001 in all three cases. Conclusions:These findings expand upon previous studies using cerebrospinal fluid by suggesting that amyloid-b and tau synergistically, rather than independently or additively, determine disease progression in the predementia phase of AD. Interestingly, the regions where such a synergismdeterminedworse clinical statuswere confined to the functional hubs of the brain’s default model network, which are postulated to be fundamental to the large-scale brain organization. [1] Pascoal.TA.et.al.Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimer’s&dementia.2016. [2] Pascoal.TA.et.al.Amyloid-beta and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease. Mol.Psychiatry 2016.