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[P3–412]: PET TAU AND AMYLOID SYNERGISM WITHIN THE DEFAULT MODE NETWORK DETERMINES THE CLINICAL STATUS IN THE PREDEMENTIA PHASE OF ALZHEIMER's DISEASE
Author(s) -
Pascoal Tharick A.,
Mathotaarachchi Sulantha S.,
Shin Monica,
Lessa Benedet Andrea,
Kang Min Su,
Ng Kok Pin,
Struyfs Hanne,
Therriault Joseph,
Soucy JeanPaul,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1629
Subject(s) - precuneus , posterior cingulate , voxel , amyloid (mycology) , neuroscience , default mode network , positron emission tomography , psychology , neuroimaging , cognition , standardized uptake value , alzheimer's disease , disease , medicine , pathology , radiology
significant associationwas observed between thevariables for females. Conclusions: Our results suggest that relatively low past BMI, especially in male, may contribute to increase of cerebral Ab burden and the risk of AD in late-life, while lower current BMI appears related with emerging neurodegeneration. The findings should be cautiously interpreted considering most of the subjects were in normal range for past and current BMI, and only small proportion of themwere in overweight or obese state.