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[P3–398]: DETERMINATION OF NEURITIC VERSUS DIFFUSE PLAQUE CONTRIBUTION TO SIGNAL DERIVED FROM CN‐FLUTEMETAMOL
Author(s) -
Ikonomovic Milos D.,
Abrahamson Eric E.,
Buckley Chris J.,
Mathis Chester,
Klunk Bill E.,
Farrar Gill
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1614
Subject(s) - chemistry , pathology , senile plaques , amyloid (mycology) , confocal , positron emission tomography , nuclear medicine , alzheimer's disease , medicine , disease , optics , physics
markers of aMCI using techniques as the event-related brain potentials (ERPs). The aim of the present study was to assess whether aMCI adults show changes, compared to healthy adults, in the ERPs recorded during the study phase of a declarative long-term memory task. Methods: Electroencephalographic recordings were obtained in 15 healthy (age: 56-84 years) and 13 aMCI (age: 5084 years) adults during an Old/New recognition task with words. Three study-test blocks were presented. During each study phase, the same 30 words (old stimuli) were presented, and participants were instructed to study and make a living/non-living judgment on words. In each test phase, the 30 studied old words and 30 unstudied new words were presented, and participants were instructed to respond pressing a different button concordant with the old/new status of the word. ERPs to the words of the study phase, that were later recognized correctly as old in the test phase, were obtained. Mean amplitudes of ERPs were measured at Fz, F3, F4, Cz, C3, C4, Pz, P3, and P4 electrode sites. Results:A left-central negative component followed by a right-frontal positive wave were identified. The mean amplitudes of the negative component (interval 310-410 ms) at Cz, C3, C4, Pz, and P4 electrode sites were significantly smaller in aMCI adults than in healthy controls. No differences were observed between groups for the mean amplitudes of the positive wave (interval 450-690 ms). Conclusions: The aMCI adults showed differences with healthy adults in the ERPs during the study phase of an Old/New recognition task with words. These differences might reflect deficit in the mobilization of processing resources for the stimuli evaluation when a task demands simultaneously to evaluate and encode the stimuli.