Premium
[P3–375]: GREY MATTER CONNECTIVITY IS ASSOCIATED WITH THE RATE OF COGNITIVE DECLINE IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Dicks Ellen,
Tijms Betty M.,
Gouw Alida A.,
Benedictus Marije R.,
Barkhof Frederik,
Scheltens Philip,
Flier Wiesje M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1591
Subject(s) - grey matter , neuropsychology , cognition , psychology , dementia , cognitive decline , cohort , betweenness centrality , audiology , medicine , magnetic resonance imaging , centrality , neuroscience , disease , statistics , white matter , mathematics , radiology
detection. Our machine learning FDG PET classifier quantifies expression of a neurodegenerative pattern that is predictive of decline (Figure 1). Tau PET has enabled assessment of pathology that may underlie variability in pattern expression and rates of decline in Am+ subjects. Methods:The AV1451 tau PET scans of 101 ADNI2 subjects (45 NL/SMC, 19 EMCI, 28 LMCI, 9 AD; 76+/-7 yrs, 40% F, 39% APOEe4 carriers) were spatially normalized along with their temporally closest FDG, MRI, and AV45 scans. FDG preceded tau scans by 1-4 years. Tau scan regions of interest were measured in structures aligned with Braak stages I– VI (Scholl, 2016) referenced to cerebellar cortex. The degree to which each subject’s FDG scan expressed a pattern reflecting AD progression was quantified using the AD Progression classifier (CV1). CV1 scores were compared across groups defined by clinical diagnosis, amyloid status, and tau Braak stage (0-2, 3, or 46). SPM t-tests were performed for the FDG scans of a) NL/ EMCI Am+Tau stage 0 to 2, b) NL/EMCI/LMCI subjects Am+Tau stage 0 to 3, and c) Am+ subjects at Tau stages 4-6 compared to NL Am-Tausubjects. Results:Am-Tausubjects had CV1 scores corresponding to a lack of AD-like pattern regardless of clinical diagnosis. CV1 scores increased with Braak stage for each diagnostic group, and across diagnostic groups at the same tau Braak stage