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[P3–374]: TAU PATHOLOGY ACCUMULATION IS PREDICTED BY A PROGRESSIVE PATTERN OF GLUCOSE HYPOMETABOLISM INITIATING IN PRECLINICAL STAGES
Author(s) -
Matthews Dawn C.,
Andrews Randolph D.,
Lukic Ana S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1590
Subject(s) - tau pathology , stage (stratigraphy) , pathology , neuroimaging , medicine , tauopathy , psychology , nuclear medicine , neuroscience , alzheimer's disease , neurodegeneration , biology , disease , paleontology
Background:Amyloid-specific PET tracers provide quantitative measurements for determining amyloid load in vivo. Many cutpoints have been proposed to define amyloid positivity; those based on post-mortem pathology are highly specific, but may not be sensitive to the initial signs of amyloid deposition. Cutpoints are also highly dependent on many analytical issues including: region of interest (ROI), reference region, partial volume correction, and the statistical criteria for choosing the cutpoint. In the absence of CT scanning, quantifying amyloid load with combined PET/MR scanners requires novel techniques for attenuation correction. We examined these aspects in a large UK sample of individuals born in the same week in 1946, all scanned on the same PET/MR scanner. Methods: PET and MR data were acquired on 250 participants enrolled in Insight 1946, a sub-study of the MRC National Survey of