Premium
[P3–364]: ACCELERATED SUBCORTICAL ATROPHY DURING AGING IN PRESYMPTOMATIC CARRIERS OF C9ORF72 MUTATION
Author(s) -
Bertrand Anne,
Wen Junhao,
Rinaldi Daisy,
Camuzat Agnès,
Fontanella Sabrina,
Routier Alexandre,
Couratier Philippe,
Pasquier Florence,
Martinaud Olivier,
Durrleman Stanley,
Brice Alexis,
Colliot Olivier,
Le Ber Isabelle
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1580
Subject(s) - c9orf72 , frontotemporal dementia , atrophy , amyotrophic lateral sclerosis , asymptomatic carrier , trinucleotide repeat expansion , mutation , dementia , medicine , oncology , asymptomatic , genetics , pathology , disease , allele , biology , gene
the reference groups (Figure 1). We evaluated HV using patchbased segmentation (Coup e et al., 2011). Finally, we used general linear models to examine if the wbGM pattern similarity of each PREVENT-AD participant with the corresponding pattern of the reference groups, the HV, or individual ROIs, was associated with CSFAb42 and p-tau levels, as well as cognitive domain scores on the RBANS. Results: The wbGM pattern metrics, but not individual ROIs GM or HV, were associated with CSF biomarkers and cognition. A wbGM pattern similar to that of the young groups was related to better immediate memory, language and attention (all p 0.03), while a pattern similar to the cognitively impaired groups was associated with increased amyloid burden (p<0.05, Table 1). Conclusions: In healthy elderly with a family history of AD, wbGM pattern appears more potent as a predictor of cognitive performance and amyloid burden than HVor individual ROI metrics. Evaluation of wholebrain structural changes may therefore hold particular interest for early identification of AD in those at risk.