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[P3–361]: DIFFERENCES BETWEEN HEALTHY AND AMNESTIC MILD COGNITIVE IMPAIRMENT ADULTS IN EVENT‐RELATED POTENTIALS DURING MEMORY ENCODING IN A VISUOSPATIAL WORKING MEMORY TASK
Author(s) -
Fernández Alba,
Díaz Fernando,
Lindín Mónica,
GaldoÁlvarez Santiago,
Zurrón Montserrat
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1577
Subject(s) - audiology , working memory , event related potential , electroencephalography , stimulus (psychology) , cognition , psychology , electrophysiology , developmental psychology , neuroscience , medicine , cognitive psychology
ambiguous (“Hard”) and unambiguous (“Easy”) words for animacy. Modulatory capacity was measured by contrasting hard vs. easy in functional activation. Age, amyloid and crystallized ability were entered in a multiple regression model for each of the 8 brain regions in the frontoparietal cognitive control network to assess whether amyloid and crystallized knowledge accounted for variance in modulation beyond age. Results:We first replicated our previous findings that older adults had decreased modulatory capacity in the frontoparietal network. After controlling for age, amyloid accumulation was related to declined modulatory capacity in parietal and right prefrontal but not left prefrontal cortex, and such depletive effects were found in middle-aged (40-60 years) but not older (60-69 years) adults. After controlling for age and continuous accumulation of amyloid, better crystallized knowledge predicted higher modulation in the frontoparietal network. Because we were particularly interested in whether the facilitating role of crystallized knowledge in modulatory capacity was related to amyloid positivity status, in a second analysis, we conducted multiple regressions with age and crystallized knowledge predicting brain modulation for amyloid negative and positive individuals, respectively.We found that better crystallized knowledge predicted higher modulatory capacity in prefrontal regions and left angular gyrus for amyloid negative individuals but only mildly (p1⁄4 0.057) in medial superior frontal gyrus for amyloid positive individuals. Conclusions: Our findings suggested that brain modulatory capability is impaired with age and amyloid. Crystallized knowledge protects modulatory capacity, which seems to have stronger effects for amyloid negative individuals, compared to amyloid positive individuals.