Premium
[P3–354]: VOXEL‐WISE ANALYSIS OF THE ASSOCIATION BETWEEN FASTING BLOOD INSULIN AND CEREBRAL GLUCOSE METABOLISM IN NONDIABETIC, COGNITIVELY NORMAL ELDERLY INDIVIDUALS
Author(s) -
Byun Min Soo,
Kim Hyun Jung,
Yi Dahyun,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Choe Young Min,
Lee Seung Hoon,
Ko Kang,
Han Na Young,
Sohn Bo Kyung,
Lee JunYoung,
Lee Younghwa,
Ko Hyunwoong,
Kim Yu Kyeong,
Lee YunSang,
Kang Koung Mi,
Sohn ChulHo,
Lee Dong Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1570
Subject(s) - medicine , insulin , endocrinology , blood sampling , diabetes mellitus , impaired fasting glucose , cardiology , insulin resistance , impaired glucose tolerance
Results:The mean ventricular and sulcal CSF volumes were 31615ml and 276643ml, respectively. The VS ratio was 0.1160.05. Pearson correlation coefficients between the natural log-transformed VS ratio and total brain volume, intracranial volume, brain parenchymal fraction, log-deep WMH, log-periventricular WMH, and age were 0.02 (p1⁄40.52), 0.18, -0.40, 0.21, 0.33, and 0.35, respectively (p-values <0.0001). The VS ratio increased with older age (p<0.0001) independent of sex, total WMH, and ICV. It was also significantly associated with poorer memory performance (b of Z-score1⁄4-1.29; 95% CI -2.41 to -0.17) and poorer executive functioning (b of Z-score1⁄4-1.72; 95% CI -2.78 to -0.67), adjusted for age, sex, log-WMH, and ICV. Conclusions:In this population, a disproportionate increase in ventricular volume relative to sulcal CSF is associated with older age and with poorer memory and executive functioning. Future studies should investigate to what extent this is a biomarker of accelerated cognitive aging.