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[P3–349]: ASSOCIATION OF SOCIABILITY WITH HIPPOCAMPAL VOLUME IN COGNITIVELY NORMAL MIDDLE‐ AND OLD‐AGED ADULTS
Author(s) -
Jung Joon Hyung,
Byun Min Soo,
Yi Dahyun,
Lee Jun Ho,
Lee Seung Hoon,
Ko Kang,
Han Na Young,
Choi Hyo Jung,
Choe Young Min,
Sohn Bo Kyung,
Lee JunYoung,
Sohn ChulHo,
Kim Yu Kyeong,
Lee Dong Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1564
Subject(s) - extraversion and introversion , psychology , precuneus , dementia , clinical dementia rating , posterior cingulate , medicine , clinical psychology , audiology , personality , neuroscience , big five personality traits , disease , cognition , social psychology
ApoE4 positive. SUVR range was 0.82-1.41 (see Figure). At a cutoff for cortical grey matter SUVR1⁄41.078, 43/240 (17.9%, 95% CI1⁄413-23%) were amyloid positive. Excluding individuals with dementia/neurological/psychiatric disease (n1⁄429), 38/211 (18.0%, 95%CI1⁄413-23%) were amyloid positive. ApoE4 positivity (OR1⁄45.1, 95%CI 2.5-11) was a major risk for amyloid positivity; childhood and midlife cognition were not. Conclusions: In this preliminary analysis the prevalence of amyloid positivity in this population based sample was w18%, slightly lower but not significantly different to that reported in a large meta-analysis of (often self-selected) healthy 70-year-olds (mean 23.1%, 95% CI1⁄419.5-27.2). Further analysis of these data will inform the design of population based approaches to disease prevention.