Premium
[P3–346]: AGING‐RELATED MICROSTRUCTURAL ALTERATIONS ALONG THE LENGTH OF THE CINGULUM BUNDLE
Author(s) -
Sibilia Francesca,
Kehoe Elisabeth,
Farrell Dervla,
Kerskens Christian,
O'Neill Desmond,
McNulty Jonathan,
Mullins Paul G.,
Bokde Arun L.W.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1561
Subject(s) - cingulum (brain) , fractional anisotropy , tractography , diffusion mri , voxel , psychology , orientation (vector space) , medicine , nuclear medicine , magnetic resonance imaging , radiology , mathematics , geometry
cognitive challenge. However, initial increases in Ab related to increased activation. As Ab burden increased further, deactivation increased again. Importantly, in the high-Ab individuals (N1⁄4 18; SUVRs > 1.11), increasing SUVR was significantly associated with lower task accuracy. Conclusions:The current study provides evidence for a dose-response, nonlinear relationship between increasing Ab burden and alteration in BOLD modulation to cognitive challenge in healthy older adults. The current findings suggest that this change in brain modulation is driven, in part, by Ab accumulation and thus may serve as a distinct biomarker for preclinical AD.