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[P3–344]: EFFECT OF KIDNEY DYSFUNCTION ON CEREBRAL CORTICAL THINNING IN AN ELDERLY POPULATION
Author(s) -
Chen ChihHao,
Chen YaFang,
Chiu MingJang,
Chen TaFu,
Tsai PingHuan,
Chen JenHau,
Yen ChungJen,
Tang SungChun,
Yeh ShinJoe,
Chen YenChing
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1559
Subject(s) - renal function , medicine , kidney disease , confidence interval , population , odds ratio , proteinuria , kidney , hyperintensity , magnetic resonance imaging , cardiology , radiology , environmental health
PiB SUVr was lower (mean6SD 1⁄41.8460.20) compared to NAWM PiB SUVr (mean6SD 1⁄42.0260.21) (paired t-test; p<0.001; Figure 1). Both the WMH and the NAWM PiB SUVr increased with age (p<0.001; Figure 2) and with the global cortical PiB SUVr, even after adjusting for age (multiple linear regression; p<0.001; Table). Conclusions: The findings support that the biologic basis of lower PiB uptake in the WMH may be associated with loss of myelin integrity in the WM. However, since myelin is lost with age, the gradual increase of WM PiB uptake with aging suggests that other aging-related mechanisms are also influencing WM PiB uptake. Contribution of WMH to the WM PiB SUVr should be considered when WM PiB uptake is used as a reference region for the evaluation of cortical PiB uptake.