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[P3–335]: INTRINSIC BRAIN NETWORKS OF COGNITIVE COMPONENTS IN SUBJECTIVE COGNITIVE DECLINE
Author(s) -
Li Xuanyu,
Zuo Xinian,
Han Ying,
Yang Liu
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1550
Subject(s) - cognition , neuropsychology , resting state fmri , posterior cingulate , effects of sleep deprivation on cognitive performance , psychology , cognitive decline , functional connectivity , neuroscience , task (project management) , brain activity and meditation , audiology , cognitive psychology , medicine , disease , electroencephalography , dementia , management , economics
unspecific brain activity. Secondly, a mixed design allows for contrasts of sustained and transient activity [1]. Thirdly, a subsequent recognition test allows for contrasts between remembered versus forgotten items, known as encoding success activity (ESA). Results: Pilot data in 60 participants (mean age 24.2 years, 36 female) showed excellent recognition memory (d’ 1⁄4 1.19, SE 1⁄4 0.05). In the auditory and visual cortex, we found sensory-specific ESA. In both sensory regions, positive ESA (remembered > forgotten) was driven by transient activations that coincided with sustained activity. In the hippocampus and default-network, we found sensoryunspecific ESA. In the hippocampus, positive ESA was driven by transient deactivations that coincided with sustained activity. In the default-network, negative ESA (forgotten > remembered) was driven by transient activations that coincided with sustained deactivations. Conclusions:These results demonstrate the feasibility to map multisensory and memory-related fMRI activity in a largescale population study. Our findings also expose some issues regarding the ambiguity of the fMRI baseline [2]. Within our mixed design, transient ESA (remembered vs. forgotten) was relatively independent from sustained activity (task vs. rest). Thus, future studies can use our paradigm to clarify the influences of age and Alzheimer’s pathology on both sustained and transient activity. [1] Visscher KM, et al. Mixed blocked/event-related designs separate transient and sustained activity in fMRI. NeuroImage 2003;19:1694–708 [2] Stark CE, Squire LR. When zero is not zero: the problem of ambiguous baseline conditions in fMRI. PNAS, 2001;98:12760–6.