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[P3–329]: NETWORK LOCALIZATION OF DEMENTIA SYMPTOMS USING A NOVEL CONNECTIVITY‐BASED META‐ANALYSIS TECHNIQUE
Author(s) -
Darby Ryan,
Fox Michael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1544
Subject(s) - frontotemporal dementia , neuroimaging , dementia , pathological , neuroscience , psychology , meta analysis , region of interest , brain mapping , disease , medicine , pathology , radiology
into 44 channels (42 x 30mm and 2 x 8mm). The Stroop task required participants to name pairs of items in the control condition and say the opposite name for the Stroop condition. Data were block averaged and mean haemodynamic response functions for each condition compared on a channel-by-channel basis. Results: Preliminary results in adults with DS aged 30-37 show that our fNIRS headgear is well tolerated and our task is accessible (9/9 participants completed it). Our results have highlighted areas showing differences in activation between Stroop and control conditions, giving targets for future region-of-interest analyses (Figure 2). We are now collecting data from a larger group of adults with DS of all ages, including individuals who are showing early signs of AD.Wewill present findings from these new studies, exploring differences in cortical activity related to age and cognitive decline. Conclusions:fNIRS is well-tolerated in adults with Down syndrome. Future work should focus on developing new paradigms for use in this population and explore resting-state activity.