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[P3–314]: INTRACRANIAL ARTERY LUMEN DIAMETER RELATES TO CEREBRAL BLOOD FLOW AND CEREBROVASCULAR REACTIVITY IN MCI
Author(s) -
Cambronero Francis E.,
Liu Dandan,
Pechman Kimberly R.,
Badami Faizan,
Watchmaker Jennifer M.,
Gordon Elizabeth A.,
Osborn Katie E.,
Hohman Timothy J.,
Davis L. Taylor,
Donahue Manus J.,
Jefferson Angela L.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1529
Subject(s) - lumen (anatomy) , medicine , cardiology , cerebral blood flow , middle cerebral artery , internal carotid artery , cerebral arteries , basilar artery , anterior cerebral artery , ischemia
independent steps. First, for each scan session (subject), the normalized signal intensity for each voxel was assessed for fit to the same session’s CSF signal across the 4 sequences (T, T, FLAIR, PD) (Fig. 2). Second, clusters ( 4 contiguous voxels) with positive vCSF regression coefficients were submitted to the morphological assessment component of the algorithm (Fig 3). For clusters surviving linearity and volume thresholds, morphological features including linearity, width, and volume of each cluster (ePVS) were extracted (Fig 3). Results:A significant correlation was found between visual counts and 1) clusters detected in the same slice (r(26)1⁄4 0.65, p<0.001; r(26)1⁄4 0.69, p<0.001; r(26)1⁄40.54, p<0.01) and 2) with total burden volume (r(26)1⁄4 0.58, p<0.01) and total ePVS number detected by mMAPS (r(26)1⁄4 0.76, p<0.01, Figure 4C). Average ePVS was 24.6 (range 3 to 71) and total burden volume (SD) 303.0 (267.74) mm per dataset. Average width of ePVS was 3.12 mm (min 1.7, max 13.5). Whole brain counts were 7.1 times that of a single slice, a nearly 100-fold increase in the range of the measured proxy variable for burden. In this limited dataset, no significant relationships were observed between