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[P3–310]: OPTIMIZING COGNITIVE CHANGE INDEX CUTOFFS BASED ON COGNITIVE DECLINE AND BIOMARKER POSITIVITY IN COGNITIVELY NORMAL OLDER ADULTS
Author(s) -
Risacher Shan L.,
West John D.,
McDonald Brenna C.,
Tallman Eileen F.,
Glazier Bradley S.,
Gao Sujuan,
Brown Steve,
Apostolova Liana G.,
Brosch Jared R.,
Farlow Martin R.,
Unverzagt Frederick W.,
Saykin Andrew J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1525
Subject(s) - cutoff , cognition , cognitive decline , episodic memory , biomarker , dementia , receiver operating characteristic , psychology , cut off , medicine , audiology , oncology , disease , psychiatry , biochemistry , chemistry , physics , quantum mechanics , power (physics)
and p value1⁄48.7 e-05 respectively). Furthermore a strong effect of baseline MMSE score on Adas0 (p value1⁄4 1e-10) was found. Conclusions:Our findings suggest that the presence of misidentification symptoms, either alone or as part of mixed presentation, increases the rate of progression, after controlling for potential confounding factors. These results support the hypothesis that psychosis subtypes have different cognitive trajectories.