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[P3–299]: AMNESTIC MILD COGNITIVE IMPAIRMENT: ASSOCIATED FACTORS WITH REMISSION TO NORMAL COGNITION IN A SAMPLE OF BRAZILIAN ELDERLY WITH LOW EDUCATIONAL LEVEL
Author(s) -
Bicalho Maria Aparecida,
Cintra Marco Túlio,
Lage Ariane,
Ávila Rafaela,
Oliveira Thayana,
Builtrago Barbara,
Alvarenga Daniel
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1513
Subject(s) - dementia , cognition , logistic regression , medicine , psychology , population , disease , psychiatry , environmental health
interaction on DTI metrics, and significant models were stratified by SCD status. Results: SCD was not associated with NFL or any DTI metrics (p-values>0.05). DTI metrics were related to NFL (p-values<0.05). There were SCD x NFL interactions on DTI metrics within the longitudinal fasciculus, corona radiata, external and capsule (all p-values<0.05). Stratified analyses revealed that in SCD individuals, higher levels of NFL was related to decreased white matter integrity compared to non-SCD individuals (p-values<0.05). Conclusions: These results highlight an association between decreased white matter health and axonal injury in non-demented older adults that is exaggerated by SCD, an early marker of AD pathology. Results suggest a possible interplay between AD and cerebrovascular pathology that occurs early within the clinical manifestation of cognitive impairment. Individuals with SCD represent an ideal target for early prevention strategies. Test, MoCA and MMSE.