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[P3–267]: FREQUENCY OF ANOSOGNOSIA AT DIAGNOSIS OF COGNITIVE IMPAIRMENT IS INFLUENCED BY COGNITIVE RESERVE
Author(s) -
Söderlund Maria Elvira,
Guajardo Maria Elena,
Adra Sofia,
Rodriguez Pablo Oscar,
Camera Luis,
Seinhart Daniel Bernardo,
Labos Edith
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1481
Subject(s) - anosognosia , dementia , medicine , confounding , medical diagnosis , neuropsychology , cognition , disease , psychiatry , clinical psychology , audiology , pathology
into 65-79 years and >80. The 65-79 years old age group were defined as Middle LOAD (MOAD) and the >80 years old group were defined as Late LOAD (LLOAD). Furthermore we aimed to investigate additional factors that may affect the rate of decline. Methods:The study used longitudinal data from the Essex Memory Clinic which included a total of 306 participants, 56 had YOAD and 249 LOAD (165 MOAD and 84 LLOAD). The rate of cognitive decline was measured using scores from theMini Mental State Examination (MMSE), and covariates included gender, years in education and vascular risk factors. The data were examined using multilevel modelling analysis. Results: At baseline, when comparing individuals with YOAD to LOAD, those with YOAD had lower MMSE scores at baseline (18.3) compared to those with LOAD (23.0; p<.001). The MOAD group had a baseline MMSE of 23.2 and the LLOADgroup 22.8 (ns). Beingmale, having better education and being diabetic were associated with higher baseline MMSE scores. The YOAD group deteriorated faster than the LOAD group (p<.001). The MOAD group declined faster than the LLOAD group despite having similar baseline MMSE scores. Conclusions: Patients with YOAD at the time of diagnosis deteriorated faster than those with LOAD. When age was split into three categories there was a gradual slowing of decline with increasing age. Of significance was that there was also a difference in the rate of decline between the MOAD and the LLOAD groups with the LLOAD group having a more benign disease course.