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[P3–265]: RATE OF DECLINE IN ALZHEIMER's DISEASE STRATIFIED BY AGE
Author(s) -
Stanley Karen,
Whitfield Tim,
Sanders Oliver,
Stevens Tim,
Walker Zuzana
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1479
Subject(s) - medicine , cognitive decline , demography , baseline (sea) , covariate , cognitive impairment , gerontology , disease , dementia , statistics , mathematics , oceanography , sociology , geology
Holm-Bonferroni correction were used. Results: MC exhibited a higher frequency (28.4% vs. 12.8%; p1⁄40.0001) and severity (mean UPDRS-III scores 2.0 vs. 0.4; p1⁄40.00007) of motor symptoms compared to NC. 13 out of 27 symptoms assessed in UPDRS-III were statistically more frequent in MC, with 7 symptoms surviving Holm-Bonferroni correction: finger taps right hand (6.9% vs. 0%; p1⁄40.001), hand movements right hand (5.7% vs. 0%; p1⁄40.0076) and left hand (6.1% vs. 0.6%; p1⁄40.039), rapid alternating movements right hand (7.7% vs. 0%; p1⁄40.0008) and left hand (9.6% vs. 0.6%; p1⁄40.0005), leg agility right leg (4.6% vs. 0%; p1⁄40.026), and gait (4.2% vs. 0%; p1⁄40.039). In cognitively asymptomatic MC (CDR Global1⁄40) rapid alternating movements right hand (3.8% vs. 0%; p1⁄40.02) and left hand (4.4% vs. 0.6%; p1⁄40.03) were more frequently impaired compared to NC after Holm-Bonferroni correction. The positive predictive value to predictMC status in cognitively asymptomatic persons with 50% a priori risk was 100% for right hand and 87.5% for left hand rapid alternating movements. In MC, highly significant positive correlations between UPDRS-III scores and EYO (rs1⁄40.409; p1⁄46.7597E-12) (increasing scores with disease duration) and CDRSOB (rs1⁄40.420; p1⁄41.3918E-12) were found. Conclusions: In ADAD, motor symptoms occur more frequently and to a larger extend. Furthermore, their degree increases with disease progression and cognitive decline. Impairment in rapid alternating hand movements is a very strong predictor of mutation carrier status in cognitively asymptomatic ADAD family members.