[P3–265]: RATE OF DECLINE IN ALZHEIMER's DISEASE STRATIFIED BY AGE

Holm-Bonferroni correction were used. Results: MC exhibited a higher frequency (28.4% vs. 12.8%; p1⁄40.0001) and severity (mean UPDRS-III scores 2.0 vs. 0.4; p1⁄40.00007) of motor symptoms compared to NC. 13 out of 27 symptoms assessed in UPDRS-III were statistically more frequent in MC, with 7 symptoms surviving Holm-Bonferroni correction: finger taps right hand (6.9% vs. 0%; p1⁄40.001), hand movements right hand (5.7% vs. 0%; p1⁄40.0076) and left hand (6.1% vs. 0.6%; p1⁄40.039), rapid alternating movements right hand (7.7% vs. 0%; p1⁄40.0008) and left hand (9.6% vs. 0.6%; p1⁄40.0005), leg agility right leg (4.6% vs. 0%; p1⁄40.026), and gait (4.2% vs. 0%; p1⁄40.039). In cognitively asymptomatic MC (CDR Global1⁄40) rapid alternating movements right hand (3.8% vs. 0%; p1⁄40.02) and left hand (4.4% vs. 0.6%; p1⁄40.03) were more frequently impaired compared to NC after Holm-Bonferroni correction. The positive predictive value to predictMC status in cognitively asymptomatic persons with 50% a priori risk was 100% for right hand and 87.5% for left hand rapid alternating movements. In MC, highly significant positive correlations between UPDRS-III scores and EYO (rs1⁄40.409; p1⁄46.7597E-12) (increasing scores with disease duration) and CDRSOB (rs1⁄40.420; p1⁄41.3918E-12) were found. Conclusions: In ADAD, motor symptoms occur more frequently and to a larger extend. Furthermore, their degree increases with disease progression and cognitive decline. Impairment in rapid alternating hand movements is a very strong predictor of mutation carrier status in cognitively asymptomatic ADAD family members.