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[P3–259]: PATTERNS OF GRAY MATTER VOLUME LOSS IN ALZHEIMER's DISEASE WITH SLEEP DISTURBANCE
Author(s) -
Yi HyonAh,
Lee Hyung
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1473
Subject(s) - pittsburgh sleep quality index , neuropsychology , audiology , sleep (system call) , cognition , effects of sleep deprivation on cognitive performance , psychology , medicine , neuroscience , sleep quality , computer science , operating system
factor was over-represented in participants with earlierversus later-than-expected AAO. Unexpectedly, participants with laterthan-expected AAO were more likely to be APOEε4 allele carriers (p1⁄40.04). Conclusions:The prevalence of measured dementia risk factors did not account for the earlier-than-expected AD dementia AAO observed in participants with a parental history of dementia. These findings imply that other participant-specific risk factors account for the variability observed in this cohort. Studies quantifying the impact of known and unknown genetic factors on AAO are required.